Turcić J, Hancević J, Antoljak T, Zic R, Alfirević I
Zagreb University School of Medicine, Department of Surgery, Clinical Hospital Center Rebro, Croatia.
Langenbecks Arch Chir. 1995;380(3):144-8. doi: 10.1007/BF00207719.
In a prospective study on 35 wounded persons we examined the effects of ozone on how well split-thickness skin grafts took in war wounds. Each of the 35 wounded persons hat at least two similar gunshot wounds, one on the lower leg or forearm and the other on the upper leg or upper arm. During the first 10 days all wounds were treated with 10% NaCl water solution dressings until the moment when healthy granulations were observed. Thereafter, the defects were covered with split-thickness skin grafts according to Thiersch. For technical reasons we treated grafts on the lower leg and forearm with ozone following the usual scheme. Grafts on the upper leg or upper arm were treated in the conventional way and they served as a control group. The results obtained in the group followed up are presented by percentage of graft takes after 10 days and accordingly compared with the results obtained in the control group. There was a higher percentage of takes in ozone-treated split-thickness skin grafts. More than 74.3% of the split-thickness skin grafts treated with ozone had a take of more than 75% of the covered surface as apposed to only 40% of the grafts treated with the conventional method. The results in these two groups were compared with a chi square matched pair test. Difference in take of the skin grafts in these two groups was statistically significant at P < 0.01.
在一项针对35名伤员的前瞻性研究中，我们研究了臭氧对战争伤口中刃厚皮片成活情况的影响。35名伤员每人至少有两处类似的枪伤，一处在小腿或前臂，另一处在大腿或上臂。在最初的10天里，所有伤口均用10%氯化钠水溶液敷料治疗，直至观察到健康的肉芽组织。此后，按照蒂尔施法用刃厚皮片覆盖缺损部位。由于技术原因，我们按照常规方案用臭氧处理小腿和前臂上的皮片。大腿或上臂上的皮片采用传统方法处理，作为对照组。随访组获得的结果以10天后皮片成活的百分比表示，并相应地与对照组获得的结果进行比较。臭氧处理的刃厚皮片成活百分比更高。用臭氧处理的刃厚皮片中，超过74.3%的皮片覆盖面积的成活比例超过75%，而采用传统方法处理的皮片这一比例仅为40%。这两组的结果用卡方配对检验进行比较。两组皮片成活情况的差异在P<0.01时具有统计学意义。
