Rosaschino F, Cisarri G, Torre R, Salvini F, Corti G
Istituto di Pediatria, Università degli Studi, Milano.
Minerva Pediatr. 1995 Mar;47(3):65-71.
The authors attempt to evaluate the degree of immune response to the first dose of anti-tetanus vaccination in young infants and to study the correlation between maternal and infantile antitetanus antibody titers. The sample studied comprised 5 males and 5 females aged between 61 and 75 days old, without acute and/or chronic pathologies and uncircumsized. Three samples of peripheral venous blood were collected for each infant: 1 at time 0, and the other two during the 15 days after the administration of the first dose of tetanus toxoid. The results support the hypothesis that vaccinal stimulation has a greater effect on cellular rather than humoral immunity, causing an increase in the CD4/CD8 ratio and a decrease in CD16. The study confirms that women with high antitetanus antibody titers during pregnancy have children with protective antibody titers. This underlines the importance of vaccinating pregnant women who, for various reasons, have not been immunised so as to prevent infantile tetanus and to allow the possibility of delaying, if necessary, the administration of the first dose of toxoid in infants without the risk of short-term toxoinfection.
作者试图评估幼儿对首剂破伤风疫苗接种的免疫反应程度，并研究母婴破伤风抗体滴度之间的相关性。所研究的样本包括5名男性和5名女性，年龄在61至75天之间，无急性和/或慢性疾病且未行包皮环切术。为每名婴儿采集三份外周静脉血样本：一份在0时刻采集，另外两份在首剂破伤风类毒素接种后的15天内采集。结果支持以下假设：疫苗刺激对细胞免疫而非体液免疫的影响更大，导致CD4/CD8比值增加和CD16减少。该研究证实，孕期破伤风抗体滴度高的女性所生子女具有保护性抗体滴度。这突出了对因各种原因未接种疫苗的孕妇进行接种的重要性，以预防婴儿破伤风，并在必要时允许在无短期毒素感染风险的婴儿中推迟首剂类毒素的接种。
