Sangpetchsong V, Vichaikummart S, Vichitnant A, Podhipak A
Southeast Asian J Trop Med Public Health. 1984 Sep;15(3):275-80.
Tetanus antitoxin was quantitatively measured in 912 pregnant women by indirect hemagglutination test. The mothers who received no dose, one dose and two doses of tetanus toxoid were 64.6%, 10.1% and 25.3% respectively. The percentage of mothers with protective antibodies in the groups receiving none, one, and two doses of tetanus toxoid were 95.4, 100 and 100. The level of protective antibody in the newborn and the magnitude of transfer rate of passive immunity to tetanus depended directly upon the level of tetanus antitoxin in maternal serum. Mothers who had tetanus antitoxin of 1.28 IU/ml or more could transfer protection to almost all of the newborns (97%-100%) irrespective of doses of tetanus toxoid administration. However, mothers who had received two doses of tetanus toxoid during pregnancy not only confer good protection but also transfer a high tetanus antitoxin levels to their newborns.
采用间接血凝试验对912名孕妇进行破伤风抗毒素定量检测。未接种、接种一剂和两剂破伤风类毒素的母亲分别占64.6%、10.1%和25.3%。未接种、接种一剂和两剂破伤风类毒素的母亲中具有保护性抗体的比例分别为95.4%、100%和100%。新生儿的保护性抗体水平以及破伤风被动免疫的转移率高低直接取决于母体血清中破伤风抗毒素的水平。破伤风抗毒素水平达到1.28 IU/ml及以上的母亲，无论破伤风类毒素的接种剂量如何，几乎都能将保护作用传递给所有新生儿（97%-100%）。然而，孕期接种两剂破伤风类毒素的母亲不仅能提供良好的保护，还能将较高水平的破伤风抗毒素传递给新生儿。
