Cadeddu G, Fioravanti P, Antonicelli R, Gasparrini P M, Gaetti R
Divisione di Medicina Geriatrica, INRCA, Ancona.
Minerva Cardioangiol. 1995 Jan-Feb;43(1-2):29-34.
The aim of our study is to evaluate whether hyperuricemia may be considered a cardiovascular risk factor also in the elderly. 370 subjects over 60-years-old of both sexes were examined of which 148 presented an ischemic heart disease and 222, age and sex homogeneous, were considered as control group. Serum uric acid was determined. A strong difference among the two groups (p < 0.001) was statistically demonstrated. Such modifications were sex independent. A strict correlation of hyperuricemia and hyper trygliceridemia was present; in fact high uric acid levels were mostly found in the group with triglycerides > 200 mg/dl (p < 0.02). In the whole group and in males a stability of uric acid was noted. In females a significant increase among the first (60-69 years) and the second (70-79 years) age class was present. In conclusion, a positive role of hyperuricemia in the ischemic heart disease pathogenesis is possible.
我们研究的目的是评估高尿酸血症是否也可被视为老年人的心血管危险因素。对370名60岁以上的男女受试者进行了检查，其中148人患有缺血性心脏病，222名年龄和性别匹配者被视为对照组。测定了血清尿酸。两组之间存在显著差异（p < 0.001），这一差异具有统计学意义。这种差异与性别无关。高尿酸血症与高甘油三酯血症之间存在密切相关性；事实上，尿酸水平高的情况大多出现在甘油三酯> 200 mg/dl的组中（p < 0.02）。在整个组和男性中，尿酸水平保持稳定。在女性中，第一个年龄组（60 - 69岁）和第二个年龄组（70 - 79岁）之间尿酸水平有显著升高。总之，高尿酸血症在缺血性心脏病发病机制中可能起到了积极作用。
