Tawata M, Nitta K, Kurihara A, Nagasaka T, Iwase E, Gan N, Inoue M, Onaya T
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Prostaglandins. 1995 Jan;49(1):27-39. doi: 10.1016/0090-6980(94)00011-k.
We evaluated acute effects of prostaglandin E1 encapsulated in lipid microspheres (lipo-PGE1), in 14 type 2 diabetic patients with neuropathy. Nerve conduction velocity (NCV), vibratory threshold (VT), skin temperature and subjective symptoms were evaluated for 24 hours after a single drip infusion of lipo-PGE1. In 6 of the 14 patients, the decrease in VT (P < 0.05) more than 50% measured by an SMV-5 vibrometer was observed at 6 hours after the infusion (responders). Subjective symptoms were improved (P < 0.05) in 5 of the 6 responders, whereas it improved in only 1 of the 8 patients who had no change in VT (nonresponders). NCV did not change (P > 0.05) either in the responders or in the nonresponders by the infusion. The responders had less impairment in VT and milder retinopathy and nephropathy than the nonresponders (P < 0.05). Our results demonstrate that vibratory sensation and subjective symptoms can be improved by a single infusion of lipo-PGE1 in type 2 diabetic patients with mild neuropathy.
我们评估了脂质微球包裹的前列腺素E1（脂微球前列地尔）对14例2型糖尿病神经病变患者的急性效应。在单次静脉滴注脂微球前列地尔后24小时内，对神经传导速度（NCV）、振动觉阈值（VT）、皮肤温度和主观症状进行评估。14例患者中有6例，在输注后6小时观察到用SMV - 5振动计测量的VT下降（P < 0.05）超过50%（反应者）。6例反应者中有5例主观症状得到改善（P < 0.05），而在8例VT无变化的患者（无反应者）中只有1例主观症状得到改善。输注后，反应者和无反应者的NCV均未改变（P > 0.05）。与无反应者相比，反应者的VT损伤较轻，视网膜病变和肾病也较轻（P < 0.05）。我们的结果表明，单次输注脂微球前列地尔可改善2型轻度神经病变糖尿病患者的振动觉和主观症状。
