Tawata M, Kurihara A, Nitta K, Iwase E, Gan N, Onaya T
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Diabetes Res Clin Pract. 1994 Dec 16;26(2):121-8. doi: 10.1016/0168-8227(94)90149-x.
Goshajinkigan, a herbal medicine, has long been used in Japan to alleviate the subjective symptoms of diabetic neuropathy; however, its effects have not been confirmed objectively. We evaluated its effects on subjective symptoms and on vibration sensation in patients with diabetic neuropathy. The oral administration of 7.5 g/day of Goshajinkigan for 3 months (treatment period) relieved subjective symptoms of numbness in 9 of 13 patients. When the drug was discontinued for 2 months as a washout period, the subjective symptom worsened in 7 of 13 patients. Chi-square analysis revealed significant effects of Goshajiniagan on subjective symptoms (P < 0.001 for numbness and P < 0.05 for cold sensation). Vibration sensation was evaluated by measuring vibratory threshold using an SMV-5 vibrometer. There were significant changes in vibratory thresholds by paired t-test (P < 0.05) both in the upper and the lower extremities during the treatment and washout periods. Chi-square analysis also revealed a significant effect of Goshajinkigan on vibratory threshold (P < 0.01). There was no significant change in glycosylated hemoglobin as a whole during the study. These observations confirm that Goshajinkigan relieves subjective symptoms and demonstrate that it improves vibration sensation in patients with diabetic neuropathy.
汉方制剂八味地黄丸长期以来一直在日本用于缓解糖尿病神经病变的主观症状；然而，其效果尚未得到客观证实。我们评估了其对糖尿病神经病变患者主观症状和振动觉的影响。每天口服7.5克八味地黄丸，持续3个月（治疗期），13名患者中有9名患者的麻木主观症状得到缓解。当停药2个月作为洗脱期时，13名患者中有7名患者的主观症状恶化。卡方分析显示八味地黄丸对主观症状有显著影响（麻木P < 0.001，冷觉P < 0.05）。使用SMV-5振动计通过测量振动阈值来评估振动觉。在治疗期和洗脱期，通过配对t检验，上肢和下肢的振动阈值均有显著变化（P < 0.05）。卡方分析还显示八味地黄丸对振动阈值有显著影响（P < 0.01）。在研究期间，糖化血红蛋白总体上没有显著变化。这些观察结果证实八味地黄丸可缓解主观症状，并表明它可改善糖尿病神经病变患者的振动觉。
