Makino K, Murakami M, Kitano I, Ushio Y
Department of Neurosurgery, Minamata Municipal General Medical Center and Hospital, Japan.
Surg Neurol. 1995 Apr;43(4):374-8. doi: 10.1016/0090-3019(95)80067-q.
Plasma-cell granulomas, which are characterized by the non-neoplastic proliferation of plasma cells, are primarily found in the lungs and upper respiratory tracts, and are extremely rare in the central nervous system.
An intracranial tumor of an 11-year-old boy was evaluated by histologic and radiologic examination.
An 11-year-old boy had a 2-month history of mild headache and nausea. A computed tomography scan showed a round, slightly high-density mass surrounded by marked edema in the left frontal lobe. On magnetic resonance imaging (MRI), the mass had a slightly high signal intensity on the T1-weighted image and marked low signal intensity on the T2-weighted image. It was heterogenously enhanced with gadolinium-DTPA. Microscopic examination demonstrated a non-neoplastic mixed cell population with a predominance of plasma cells. Immunohistochemical staining revealed that it was characterized by a polyclonal plasma cell population.
Our extensive search of the literature indicated this to be the ninth reported case of intracranial plasma cell granulation. The MRI was very useful for evaluating the extent of the intracranial lesions. The tumor was removed surgically and did not recur during a 2-year follow-up with no radiation therapy.
浆细胞肉芽肿以浆细胞的非肿瘤性增殖为特征，主要见于肺部和上呼吸道，在中枢神经系统极为罕见。
对一名11岁男孩的颅内肿瘤进行了组织学和放射学检查。
一名11岁男孩有2个月的轻度头痛和恶心病史。计算机断层扫描显示左额叶有一个圆形、略高密度的肿块，周围有明显水肿。在磁共振成像（MRI）上，该肿块在T1加权图像上呈略高信号强度，在T2加权图像上呈明显低信号强度。用钆喷酸葡胺增强扫描呈不均匀强化。显微镜检查显示为非肿瘤性混合细胞群，以浆细胞为主。免疫组织化学染色显示其特征为多克隆浆细胞群。
我们广泛查阅文献表明，这是第九例报告的颅内浆细胞肉芽肿病例。MRI对评估颅内病变范围非常有用。该肿瘤通过手术切除，在未进行放射治疗的2年随访期间未复发。
