Young M
Baker Medical Research Institute, Prahran, Australia.
Steroids. 1995 Jan;60(1):133-6. doi: 10.1016/0039-128x(94)00029-c.
Uninephrectomized rats maintained on 0.9% NaCl as drinking fluid and infused for 8 weeks with aldosterone 0.75 micrograms/h via subcutaneous osmotic minipumps respond with hypertension, cardiac hypertrophy, and both interstitial and perivascular cardiac fibrosis. Similar animals injected with desoxycorticosterone (20 mg/week), or the glucocorticoid antagonist RU 486 (2 mg/day) show interstitial cardiac fibrosis to a lesser degree than animals injected with aldosterone, and show perivascular fibrosis to a greater degree. These findings suggest that glucocorticoid antagonist activity may play a role in exacerbating perivascular collagen deposition in response to chronic mineralocorticoid and salt imbalance.
将饮用液体维持为0.9%氯化钠并通过皮下渗透微型泵以0.75微克/小时的速度输注醛固酮8周的单侧肾切除大鼠会出现高血压、心脏肥大以及间质和血管周围心脏纤维化。注射脱氧皮质酮（20毫克/周）或糖皮质激素拮抗剂RU 486（2毫克/天）的类似动物，与注射醛固酮的动物相比，间质心脏纤维化程度较轻，而血管周围纤维化程度较重。这些发现表明，糖皮质激素拮抗剂活性可能在因慢性盐皮质激素和盐失衡而加剧血管周围胶原沉积中起作用。
