Björnberg A, Hellgren L
Z Hautkr. 1975;Suppl 2:13-5.
This trial was designed to evaluate the clinical effect of a new Topical steroid, the desoximetasone (test name A 41 304 from Hoechst Aktiengesellschaft). A randomized, double-blind, right-left comparative trial has been carried out in 22 patients with atopic dermatitis and on 24 patients with psoriasis. As a comparative drug, a betamethasone 17-valerate preparation, being the strongest on the market, has been used. The new compound showed a better effect on both indications, the difference being significant (p less than 0,005) on psoriasis.
本试验旨在评估一种新型外用类固醇药物——去氧米松(商品名A 41 304,由赫斯特股份公司生产)的临床效果。在22例特应性皮炎患者和24例银屑病患者中进行了一项随机、双盲、左右对比试验。作为对照药物,使用了市场上效力最强的倍他米松17-戊酸酯制剂。新化合物在两种适应症上均显示出更好的效果,在银屑病方面差异具有显著性(p<0.005)。