Ciuffetti G, Pasqualini L, Fuscaldo G, Piccioni N, Paltriccia R, Mannarino E
II Department of Internal Medicine, University of Perugia, Italy.
Vasa. 1995;24(2):155-8.
In order to see whether leucocyte-derived adhesion molecules are involved in ischaemia and reperfusion, the total and differential leucocyte counts and expression of the LFA complex i.e. CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1) and CD11c/CD18 (p 150,95) were monitored before and after standard cold and heat tests in 8 females with Raynaud's Disease and 8 matched controls. All patients suffered from vasoconstriction during the cold test which, compared with controls, was associated with fewer granulocytes expressing significantly more CD11b/CD18 (Mac-1) integrin and a significant degree of neutropenia persisting during reperfusion. Leucocyte-endothelial adhesive interactions may therefore occur during ischaemia and reperfusion.
为了观察白细胞衍生的黏附分子是否参与缺血和再灌注过程，我们对8名雷诺病女性患者和8名匹配的对照者进行了标准的冷热试验，并在试验前后监测了白细胞总数、分类计数以及淋巴细胞功能相关抗原（LFA）复合物的表达，即CD11a/CD18（LFA-1）、CD11b/CD18（Mac-1）和CD11c/CD18（p150,95）。所有患者在冷试验期间均出现血管收缩，与对照组相比，粒细胞数量减少，表达显著更多的CD11b/CD18（Mac-1）整合素，并且在再灌注期间存在明显程度的中性粒细胞减少。因此，白细胞与内皮细胞的黏附相互作用可能在缺血和再灌注过程中发生。
