Grasedyck K
Medizinische Kernklinik und Poliklinik UKE, Hamburg.
Z Rheumatol. 1995 Mar-Apr;54(2):110-6.
Long-term effects of disease-modifying antirheumatic drugs are not at all satisfactory. Therefore combinations of different substances have long been studied. But no convincing recommendations could be derived from those results. Some combinations seem to be more effective than the single substances, but often have more side-effects. First of all, those types of rheumatoid arthritis must be defined which require an aggressive therapy. These may profit from combinations with sulfasalazine, methotrexate or azathioprine. But such questions may only be answered by long-term studies which can be statistically evaluated.
改善病情抗风湿药物的长期效果并不尽如人意。因此，不同药物组合的研究由来已久。但从这些研究结果中无法得出令人信服的建议。有些组合似乎比单一药物更有效，但往往副作用更多。首先，必须明确哪些类型的类风湿性关节炎需要积极治疗。这些类型的关节炎可能会从与柳氮磺胺吡啶、甲氨蝶呤或硫唑嘌呤的联合使用中获益。但这类问题只有通过能够进行统计学评估的长期研究才能得到解答。
