Wang P J, Tseng C L, Young C, Liu H M, Chang Y C, Shen Y Z, Lee C Y
Department of Pediatrics, Radiology, National Taiwan University Hospital, Taipei.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1995 Mar-Apr;36(2):93-100.
Four female children with clinically-definite diagnoses of multiple sclerosis (MS) were studied with multimodal evoked potentials (EPs), electroencephalogram (EEG), cerebrospinal fluid (CSF) analysis, computed tomography (CT) and magnetic resonance imaging (MRI). Correlations among the clinical features, neuroimaging and neurophysiological studies were also evaluated. Their ages of the onset ranged from 5 to 11 years. The clinical evolution in the all four MS cases was relapsing-remitting form. MRI studies in three cases showed abnormal demyelinating plaques in the brainstem, cerebellum and white matter of the cerebrum. CT examination, performed in the other MS case, did not reveal hypodensic lesion. Despite that MRI failed to document optical nerve lesions, three cases had abnormal visual evoked potentials (VEPs). Somatosensory evoked potentials (SSEPs) were abnormal in three cases. Brainstem auditory evoked potentials (BAEPs) were abnormal in two cases presenting with signs of brainstem dysfunction. The conclusion was that paraclinical evidences obtained from MRI and multimodal evoked potential studies are of value as an aid in localizing involved areas and detecting silent lesions in children with MS.
对4例临床确诊为多发性硬化症（MS）的女童进行了多模式诱发电位（EPs）、脑电图（EEG）、脑脊液（CSF）分析、计算机断层扫描（CT）和磁共振成像（MRI）研究。还评估了临床特征、神经影像学和神经生理学研究之间的相关性。她们的发病年龄在5至11岁之间。所有4例MS病例的临床病程均为复发缓解型。3例的MRI研究显示脑干、小脑和大脑白质有异常脱髓鞘斑块。另一例MS病例的CT检查未发现低密度病变。尽管MRI未能记录到视神经病变，但3例有异常视觉诱发电位（VEP）。3例体感诱发电位（SSEP）异常。2例有脑干功能障碍体征的病例脑干听觉诱发电位（BAEP）异常。结论是，从MRI和多模式诱发电位研究中获得的辅助临床证据有助于定位MS患儿的受累区域并检测无症状病变。
