Comi G, Martinelli V, Medaglini S, Locatelli T, Filippi M, Canal N, Triulzi F, Del Maschio A
Department of Neurology, Istituto Scientifico San Raffaele, University of Milan, Italy.
J Neurol. 1989 Jan;236(1):4-8. doi: 10.1007/BF00314209.
Sixty multiple sclerosis (MS) patients (33 definite, 13 probale and 14 suspected were investigated by computed tomography (CT), magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid (CSF) electrophoresis. MRI abnormalities were found in 50 cases, while at least one abnormal evoked potential was detected in each of 52 cases. Brain-stem auditory evoked potentials were more sensitive than MRI for the detection of brain-stem involvement. All the patients with oligoclonal bands had abnormal MRI and none of the patients with normal MRI had oligoclonal bands in the CSF. The number and the extent of MRI lesions were significantly correlated with the duration of disease and with the degree of disability. Our observations stress the importance of the combined use of MRI and EPs in detecting silent CNS lesions in MS patients.
对60例多发性硬化症（MS）患者（33例确诊，13例疑似，14例可能）进行了计算机断层扫描（CT）、磁共振成像（MRI）、多模式诱发电位（EPs）和脑脊液（CSF）电泳检查。50例发现MRI异常，52例中每例至少检测到一项异常诱发电位。脑干听觉诱发电位在检测脑干受累方面比MRI更敏感。所有寡克隆带阳性的患者MRI均异常，MRI正常的患者CSF中均无寡克隆带。MRI病变的数量和范围与疾病持续时间和残疾程度显著相关。我们的观察结果强调了联合使用MRI和EPs在检测MS患者无症状中枢神经系统病变中的重要性。
