dos Reis R M, Foss M C, de Moura M D, Ferriani R A, Silva de Sá M F
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Gynecol Endocrinol. 1995 Mar;9(1):45-50. doi: 10.3109/09513599509160190.
Insulin resistance has been reported to be associated with hyperandrogenism and polycystic ovaries. To study the prevalence of insulin resistance in patients with polycystic ovary syndrome (PCO) and the correlation between hyperinsulinemia and hyperandrogenism, 48 patients were divided into four groups: group 1, non-obese ovulatory women (n = 10); group 2, obese ovulatory women (n = 9); group 3, non-obese women with PCO (n = 14); group 4, obese women with PCO (n = 15). Each patient was submitted to an oral glucose tolerance test (OGTT). Glucose, insulin, androstenedione and testosterone levels were determined and the blood glucose and insulin response of women with PCO and normal women were compared. Glucose intolerance was observed in group 3 (28.6%) and group 4 (40%) but not in groups 1 or 2, and hyperinsulinemia was observed in group 2 (66.7%), group 3 (64.3%) and group 4 (86.6%). There was a correlation between androstenedione and testosterone levels and insulinemia in group 4. There was also a high prevalence of insulin resistance in patients with PCO regardless of obesity, and hyperandrogenism-aggravated insulin resistance.
据报道，胰岛素抵抗与高雄激素血症和多囊卵巢有关。为研究多囊卵巢综合征（PCO）患者胰岛素抵抗的患病率以及高胰岛素血症与高雄激素血症之间的相关性，将48例患者分为四组：第1组，非肥胖排卵女性（n = 10）；第2组，肥胖排卵女性（n = 9）；第3组，非肥胖PCO女性（n = 14）；第4组，肥胖PCO女性（n = 15）。每位患者均接受口服葡萄糖耐量试验（OGTT）。测定葡萄糖、胰岛素、雄烯二酮和睾酮水平，并比较PCO女性和正常女性的血糖和胰岛素反应。第3组（28.6%）和第4组（40%）观察到葡萄糖耐量异常，而第1组或第2组未观察到，第2组（66.7%）、第3组（64.3%）和第4组（86.6%）观察到高胰岛素血症。第4组中雄烯二酮和睾酮水平与胰岛素血症之间存在相关性。无论是否肥胖，PCO患者中胰岛素抵抗的患病率也很高，且高雄激素血症会加重胰岛素抵抗。
