Boudreaux Monique Y, Talbott Evelyn O, Kip Kevin E, Brooks Maria M, Witchel Selma F
Curr Diab Rep. 2006 Feb;6(1):77-83. doi: 10.1007/s11892-006-0056-1.
Women with polycystic ovary syndrome (PCOS) often develop type 2 diabetes mellitus (T2DM). To determine the magnitude of risk of developing T2DM among women with PCOS, development of T2DM was prospectively assessed among women who had T2DM (n = 97) and controls (n = 95) using Kaplan-Meier survival analysis and Cox proportional hazards modeling. The women with T2DM had higher baseline weight (body mass index, P < 0.01) and lower insulin sensitivity (homeostasis assessment model of insulin resistance, P < 0.01). The 8-year incidence rate among cases and controls was 13.4% and 5.8%, respectively (relative risk = 2.3). Obese cases had a fivefold risk of T2DM developing (P < 0.01) compared with age-adjusted obese controls, indicating significant interaction between PCOS and obesity to effect T2DM risk.
多囊卵巢综合征（PCOS）女性常患2型糖尿病（T2DM）。为确定PCOS女性患T2DM的风险程度，采用Kaplan-Meier生存分析和Cox比例风险模型，对患有T2DM的女性（n = 97）和对照组女性（n = 95）进行前瞻性评估，以了解T2DM的发病情况。患有T2DM的女性基线体重更高（体重指数，P < 0.01），胰岛素敏感性更低（胰岛素抵抗稳态评估模型，P < 0.01）。病例组和对照组的8年发病率分别为13.4%和5.8%（相对风险 = 2.3）。与年龄调整后的肥胖对照组相比，肥胖病例患T2DM的风险高出五倍（P < 0.01），表明PCOS与肥胖之间存在显著的相互作用，从而影响T2DM风险。
