Benjamin J, Levine J, Fux M, Aviv A, Levy D, Belmaker R H
Soroka Medical Center, Kupat Holim Sick Fund of the Histadrut, Beersheba, Israel.
Am J Psychiatry. 1995 Jul;152(7):1084-6. doi: 10.1176/ajp.152.7.1084.
Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.
Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.
The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.
The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.
由于他们在早期研究中发现，肌醇（一种重要的细胞内第二信使前体）在开放试验和双盲试验中对抑郁症有效，作者研究了其对惊恐障碍的有效性。
21名伴有或不伴有广场恐惧症的惊恐障碍患者完成了一项双盲、安慰剂对照、为期4周、随机分配的交叉治疗试验，试验内容为每天服用12克肌醇。
与服用安慰剂后相比，服用肌醇后惊恐发作的频率和严重程度以及广场恐惧症的严重程度显著下降更多。副作用极小。
作者得出结论，肌醇的疗效、无明显副作用以及肌醇是人类饮食中的天然成分这一事实，使其成为治疗惊恐障碍的一种潜在有吸引力的疗法。
