Fux M, Levine J, Aviv A, Belmaker R H
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Am J Psychiatry. 1996 Sep;153(9):1219-21. doi: 10.1176/ajp.153.9.1219.
Earlier studies reported that inositol, a simple polyol second messenger precursor, was effective in controlled trials for patients with depression and panic. In this study its effectiveness in obsessive-compulsive disorder was investigated.
Thirteen patients with obsessive-compulsive disorder completed a double-blind, controlled crossover trial of 18 g/day of inositol or placebo for 6 weeks each.
The subjects had significantly lower scores on the Yale-Brown Obsessive Compulsive Scale when taking inositol than when taking placebo.
The authors conclude that inositol is effective in depression, panic, and obsessive-compulsive disorder, a spectrum of disorders responsive to selective serotonin reuptake inhibitors.
早期研究报告称，肌醇作为一种简单的多元醇第二信使前体，在抑郁症和恐慌症患者的对照试验中显示出有效性。本研究对其在强迫症中的有效性进行了调查。
13名强迫症患者完成了一项双盲、对照交叉试验，分别服用每日18克肌醇或安慰剂，各为期6周。
与服用安慰剂时相比，受试者服用肌醇时在耶鲁-布朗强迫症量表上的得分显著更低。
作者得出结论，肌醇对抑郁症、恐慌症和强迫症有效，这些疾病都对选择性5-羟色胺再摄取抑制剂有反应。
