Rachev E
Akush Ginekol (Sofiia). 1994;33(3):45-7.
The author presents his experience in the treatment of 21 early postmenopausal women (mean age of 49.2 yrs) with transdermal delivery of 17 beta-oestradiol (Estraderm TTS, Ciba). During the treatment Kuppermann index falls from 28.5 to 10.9. Karyopyknotic index increases from 6.8 to 23.4 and maturation index moves from 39:52:9 to 0:71:29. Genital bleeding occurs in 52% of the patients. The author concludes that the treatment with transdermal delivery of oestradiol could be used more widely for replacement therapy in the postmenopause.
作者介绍了他对21名绝经后早期女性（平均年龄49.2岁）采用经皮递送17β-雌二醇（诺坤复透皮贴剂，汽巴公司生产）进行治疗的经验。治疗期间，库珀曼指数从28.5降至10.9。核固缩指数从6.8增至23.4，成熟指数从39:52:9变为0:71:29。52%的患者出现生殖器出血。作者得出结论，经皮递送雌二醇治疗可更广泛地用于绝经后的替代治疗。
