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已知腹主动脉瘤破裂:一个伦理困境。

Rupture of known abdominal aortic aneurysms: an ethical dilemma.

作者信息

Piotrowski J J, Akhrass R, Alexander J J, Yuhas J P, Brandt C P

机构信息

Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109, USA.

出版信息

Am Surg. 1995 Jul;61(7):556-9.

PMID:7793733
Abstract

Elderly patients with abdominal aortic aneurysms (AAA) may be deemed inoperable due to the presence of comorbid conditions. Presentation of these patients with acute rupture can then result in difficult ethical decisions regarding surgical treatment. Over six years, 80 patients were treated emergently for ruptured AAA. Of these patients, 26 (32.5%) had known aneurysms. This study was performed to determine outcome and factors affecting mortality in patients with known AAAs. There were no significant differences between known and unknown AAA groups with regard to operative risk. In the overall group (n = 80), patient delay in seeking treatment averaged 20.4 hours with a trend towards shorter times in those with known AAAs (13.8 hours) compared with the unknown group (23.6 hours; p = 0.09). Medical transport delay, however, was significantly shorter for patients with known AAA (124 minutes versus 230 minutes; p = 0.04). Overall mortality was 56 per cent (n = 45). Those patients with known AAAs had a higher mortality (69%; n = 18) than those with unknown AAAs (50%, n = 27) but this was not statistically significant (P = 0.10). In patients with known AAAs, operative death was related to patient delay, with an average delay in seeking medical advice of 21.3 hours in nonsurvivors compared with 8.6 hours in survivors (P = 0.04). No other risk or demographic factors correlated with mortality. Despite a known AAA, significant delay in seeking medical advice occurred, and this delay resulted in decreased survival. Patient education is imperative if nonoperative treatment is chosen.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

患有腹主动脉瘤(AAA)的老年患者可能因并存疾病而被视为无法进行手术。这些患者急性破裂时,就手术治疗而言,会导致艰难的伦理决策。在六年时间里,80例患者因AAA破裂接受了急诊治疗。在这些患者中,26例(32.5%)患有已知动脉瘤。本研究旨在确定已知AAA患者的治疗结果及影响死亡率的因素。已知和未知AAA组在手术风险方面无显著差异。在整个研究组(n = 80)中,患者寻求治疗的延迟平均为20.4小时,已知AAA患者(13.8小时)与未知组(23.6小时)相比有时间缩短的趋势(p = 0.09)。然而,已知AAA患者的医疗转运延迟明显更短(124分钟对230分钟;p = 0.04)。总体死亡率为56%(n = 45)。已知AAA的患者死亡率(69%;n = 18)高于未知AAA的患者(50%,n = 27),但差异无统计学意义(P = 0.10)。在已知AAA的患者中,手术死亡与患者延迟有关,非幸存者寻求医疗建议的平均延迟为21.3小时,而幸存者为8.6小时(P = 0.04)。没有其他风险或人口统计学因素与死亡率相关。尽管已知患有AAA,但寻求医疗建议仍出现了显著延迟,这种延迟导致生存率降低。如果选择非手术治疗,患者教育势在必行。(摘要截短至250字)

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引用本文的文献

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BMC Med Ethics. 2023 Jan 9;24(1):1. doi: 10.1186/s12910-022-00881-x.
2
Do scoring systems help in predicting survival following ruptured abdominal aortic aneurysm surgery?评分系统对预测腹主动脉瘤破裂手术后的生存率有帮助吗?
Ann R Coll Surg Engl. 2009 Mar;91(2):123-7. doi: 10.1308/003588409X359376. Epub 2008 Dec 19.
3
Will endovascular repair replace open surgery for abdominal aortic aneurysm repair?
血管内修复术会取代腹主动脉瘤修复的开放手术吗?
Ann Surg. 2000 Oct;232(4):501-7. doi: 10.1097/00000658-200010000-00005.