Moulin G, Thomas L, Vigneau M, Fiere A
Service de Dermatologie, Hôpital de l'Antiquaille, Lyon.
Ann Dermatol Venereol. 1994;121(10):721-3.
Cutaneous elastosis with cysts and comedones (Favre-Racouchot) is one of the oldest known manifestations of helioderma. Both sides of the face are usually involved symmetrically.
We observed a 65-year-old woman with extremely severe Favre-Racouchot disease localized exclusively on the left side of the face. The diagnosis of elastosis with cysts and comedones was confirmed histologically. This elastosis with cysts and comedones was associated with spasms of the hemiface treated with injections of botulinic toxin. This association was fortuitous and we retained actinic irradiation as the causal agent in this woman who had worked for 15 years in the same room. The elastosis occurred on the side of the face which had been continuously exposed at the same orientation to the window.
This original observation is similar to cases where facial exposure to artificial light or sunlight is asymmetrical, leading to a higher incidence of lesions on one side of the face: colloid milium, actinic keratosis, Dubreuilh melanoma (malignant lentigo) or simple helioderma. The asymmetrical nature of the actinic lesions is often related to automobile driving. This case was particular since it demonstrated that Favre-Racouchot elastosis with cysts and comedones is due to actinic irradiation and not to skin aging.
伴有囊肿和粉刺的皮肤弹性组织变性(法夫尔 - 拉库肖病)是已知最古老的日光性皮肤病表现之一。面部两侧通常对称受累。
我们观察到一名65岁女性,患有极其严重的法夫尔 - 拉库肖病,仅局限于面部左侧。经组织学证实为伴有囊肿和粉刺的弹性组织变性。这种伴有囊肿和粉刺的弹性组织变性与通过注射肉毒杆菌毒素治疗的半侧面部痉挛相关。这种关联是偶然的,我们认为在同一房间工作15年的该女性中,光化性照射是病因。弹性组织变性发生在面部持续以相同方向朝向窗户暴露的一侧。
这一独特观察结果类似于面部暴露于人造光或阳光不对称的情况,导致面部一侧病变发生率更高:胶样粟丘疹、光化性角化病、杜布雷伊黑素瘤(恶性雀斑样痣)或单纯日光性皮肤病。光化性病变的不对称性质通常与汽车驾驶有关。该病例很特殊,因为它表明伴有囊肿和粉刺的法夫尔 - 拉库肖弹性组织变性是由光化性照射引起的,而非皮肤老化。