单独及与乙胺嘧啶联合使用时，磺胺嘧啶及其代谢产物对刚地弓形虫的体外作用。
In vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii.
作者信息
Schoondermark-van de Ven E, Vree T, Melchers W, Camps W, Galama J
机构信息
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1995 Mar;39(3):763-5. doi: 10.1128/AAC.39.3.763.
Sulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadiazine, 5-OH-sulfadiazine, 5-OH-glucuronide-sulfadiazine, and 5-OH-sulfate-sulfadiazine were tested separately and in combination with pyrimethamine for the inhibitory activity on Toxoplasma gondii growth in vitro. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed anti-Toxoplasma activity. The addition of 0.05 micrograms of pyrimethamine per ml, a concentration which in itself is not inhibitory, potentiated the microbial activity of sulfadiazine and its metabolites 100 fold.
分别对磺胺嘧啶及其代谢产物N4-乙酰磺胺嘧啶、4-羟基磺胺嘧啶、5-羟基磺胺嘧啶、5-羟基葡萄糖醛酸磺胺嘧啶和5-羟基硫酸磺胺嘧啶进行了测试，并将它们与乙胺嘧啶联合用于体外抑制刚地弓形虫生长的活性测试。除N4-乙酰磺胺嘧啶外，所有磺胺类化合物均具有抗弓形虫活性。每毫升添加0.05微克乙胺嘧啶（该浓度本身无抑制作用）可使磺胺嘧啶及其代谢产物的抗菌活性增强100倍。
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