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A template for the protein kinase family.蛋白激酶家族的一个模板。
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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.与MgATP和肽抑制剂复合的环磷酸腺苷依赖性蛋白激酶催化亚基的晶体结构。
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Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.酿酒酵母中的三种不同基因编码环磷酸腺苷依赖性蛋白激酶的催化亚基。
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Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase.编码环磷酸腺苷依赖性蛋白激酶亚基的酿酒酵母基因的表征
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一种丝氨酸（苏氨酸）蛋白激酶赋予植物病原真菌玉米黑粉菌抗真菌剂的能力。

A serine (threonine) protein kinase confers fungicide resistance in the phytopathogenic fungus Ustilago maydis.

作者信息

Orth A B, Rzhetskaya M, Pell E J, Tien M

机构信息

Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA.

出版信息

Appl Environ Microbiol. 1995 Jun;61(6):2341-5. doi: 10.1128/aem.61.6.2341-2345.1995.

DOI:10.1128/aem.61.6.2341-2345.1995
PMID:7793954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC167505/
Abstract

A mutant of Ustilago maydis (VR43) with single-gene resistance to the dicarboximide fungicide vinclozolin was previously isolated and characterized. A genomic library was constructed, and an 8.7-kb resistance-conferring fragment was isolated by sib selection. Sequencing this fragment, we identified an 1,218-bp open reading frame, which, if disrupted by deletion, no longer confers resistance. Analyses of the data in GenBank demonstrated a high degree of homology between the product of the 1,218-bp open reading frame, referred to as the adr-1 gene, and Ser (Thr) protein kinases.

摘要

先前已分离并鉴定出一种对二羧酰亚胺类杀菌剂乙烯菌核利具有单基因抗性的玉米黑粉菌突变体（VR43）。构建了一个基因组文库，并通过亚克隆筛选分离出一个8.7kb的抗性赋予片段。对该片段进行测序后，我们鉴定出一个1218bp的开放阅读框，如果通过缺失将其破坏，则不再赋予抗性。对GenBank中的数据进行分析表明，这个被称为adr-1基因的1218bp开放阅读框的产物与丝氨酸（苏氨酸）蛋白激酶之间具有高度同源性。