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[乙状结肠癌肝转移瘤的新辅助化疗:顺铂/5-氟尿嘧啶动脉内灌注治疗后肝切除的病例报告]

[Neoadjuvant chemotherapy of liver tumors metastasized by sigmoid colon cancer: a case report of CDDP/5-FU intraarterial infusion therapy followed by hepatectomy].

作者信息

Yamashita F, Tanaka M, Yutani S, Shimada M, Kusaba T, Kuroki S, Inoue J, Katoh O, Sasatomi K, Tanikawa K

机构信息

Dept. of Internal Medicine, Social Insurance Saga Hospital.

出版信息

Gan To Kagaku Ryoho. 1995 Jun;22(7):949-52.

PMID:7794002
Abstract

A case of liver tumors metastasized by Sigmoid colon cancer was treated with intrahepatic arterial infusion of CDDP (10 mg) and 5-FU (250 mg) via subcutaneously implanted reservoir. After 20 administrations of CDDP and 5-FU, the tumors in the right lobe of the liver disappeared, but those in the left lobe remained. Therefore left hepatectomy was carried out. Six months after the hepatectomy, a nodule recurrence was disclosed in the right lobe of the liver. With re-elevated serum CEA level, subsequent intrahepatic arterial infusion of CDDP and 5-FU the nodule size reduced with normalization of the serum CEA level.

摘要

一例乙状结肠癌肝转移瘤患者,通过皮下植入的储液器进行肝动脉灌注顺铂(10mg)和5-氟尿嘧啶(250mg)治疗。在进行20次顺铂和5-氟尿嘧啶给药后,肝右叶肿瘤消失,但左叶肿瘤仍存在。因此进行了左肝切除术。肝切除术后6个月,肝右叶出现结节复发。随着血清癌胚抗原(CEA)水平再次升高,随后再次进行肝动脉灌注顺铂和5-氟尿嘧啶治疗,结节大小缩小,血清CEA水平恢复正常。

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