Friedlander R C, Olson L D
Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Avian Dis. 1995 Jan-Mar;39(1):141-4.
When turkeys were inoculated intramuscularly with live Pasteurella multocida, three of the four inoculated turkeys developed an increase in modified Russell's viper venom time (mRVVT) 24 hours after inoculation. This increase was followed by irregular decreases and increases in mRVVT at subsequent bleedings. When turkeys were inoculated intravenously with P. multocida, the mRVVT increased markedly after inoculation in all eight inoculated turkeys: 9 hours later, the average mRVVT was significantly (P < 0.05) higher than that of the uninoculated turkeys. No microthrombi were observed in the blood vessels of the liver, spleen, kidneys, or lungs. An increase in mRVVT was interpreted as an excessive consumption of one or more of clotting factors X, V, II, and I. These results indicate that consumptive coagulopathy could be a factor in the pathogenesis of fowl cholera in turkeys.
当用多杀性巴氏杆菌活菌对火鸡进行肌肉注射接种时，四只接种的火鸡中有三只在接种后24小时出现改良罗素蝰蛇毒时间（mRVVT）增加。这种增加之后，在随后的采血中mRVVT出现不规则的下降和上升。当用火鸡静脉注射多杀性巴氏杆菌时，所有八只接种的火鸡在接种后mRVVT均显著增加：9小时后，平均mRVVT显著高于未接种的火鸡（P < 0.05）。在肝脏、脾脏、肾脏或肺部的血管中未观察到微血栓。mRVVT增加被解释为凝血因子X、V、II和I中的一种或多种过度消耗。这些结果表明，消耗性凝血病可能是火鸡禽霍乱发病机制中的一个因素。
