Rhoades K R, Rimler R B
Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010.
Avian Dis. 1993 Oct-Dec;37(4):1071-3.
Relatively little information is available on Pasteurella multocida virulence factors involved in producing fowl cholera. Because of the complex nature of bacterial pathogenesis, the recommended approach for ascertaining these factors is to compare biological attributes of high- and low-virulence strains. To permit use of this approach for fowl cholera, P. multocida strains of high and low virulence were identified. Turkey poults were exposed intrapharyngeally and intravenously (IV) to two antigenically and biochemically similar strains. Based on mortality, strain P-1059 was highly virulent and strain P-1062 was avirulent. Microbiological examination indicated that only the virulent strain infected the pharyngeal mucosa of intrapharyngeally exposed poults and survived and multiplied in IV-exposed poults. These findings indicate strain differences in those virulence factors concerned with the colonization and multiplication stages of disease development.
关于多杀性巴氏杆菌在引发禽霍乱中所涉及的毒力因子，目前可获取的信息相对较少。由于细菌致病机制的复杂性，确定这些因子的推荐方法是比较高毒力菌株和低毒力菌株的生物学特性。为了能将此方法用于禽霍乱研究，已鉴定出多杀性巴氏杆菌的高毒力和低毒力菌株。将幼火鸡经咽内和静脉内（IV）接种两种抗原性和生化特性相似的菌株。根据死亡率，P - 1059菌株具有高毒力，P - 1062菌株无毒力。微生物学检查表明，只有毒力菌株感染了经咽内接种幼火鸡的咽黏膜，并在经静脉接种的幼火鸡体内存活和繁殖。这些发现表明，在与疾病发展的定植和繁殖阶段相关的毒力因子方面存在菌株差异。
