Biggar R J, Mortimer E A, Haughie G E
Am J Epidemiol. 1976 Jul;104(1):28-33. doi: 10.1093/oxfordjournals.aje.a112271.
The geographic distribution of infants born with anencephaly and spina bifida in Rochester, New York, in 1924-1932, was examined to test the hypothesis that iodine supplemented water may have reduced the prevalence of these defects. During this period the region had a high prevalence of iodine deficiencies. Comparing the prevalence of neural tube defects in an area with iodine supplemented water to one without iodine supplementation, we found no significant difference in prevalence at birth of neural tube defects. Because the prevalence rates for these defects in children of foreign-born parents (except the Irish) was low, we reexamined the data, excluding these cases. There remained no differences in rates. Iodine supplemented water thus appears to have had no effect on the occurrence of neural tube defects.
对1924年至1932年纽约罗切斯特市无脑儿和脊柱裂患儿的地理分布进行了研究，以检验补充碘的水可能降低这些缺陷患病率这一假设。在此期间，该地区碘缺乏症的患病率很高。将饮用补充碘水地区的神经管缺陷患病率与未补充碘地区的患病率进行比较，我们发现出生时神经管缺陷的患病率没有显著差异。由于外国出生父母（爱尔兰人除外）的子女中这些缺陷的患病率较低，我们重新审查了数据，排除了这些病例。患病率仍然没有差异。因此，补充碘的水似乎对神经管缺陷的发生没有影响。
