Shankaran S, Liang K C, Ilagan N, Fleischmann L
Wayne State University School of Medicine, Department of Pediatrics, Detroit, Michigan, USA.
Pediatr Nephrol. 1995 Apr;9(2):159-62. doi: 10.1007/BF00860731.
Mineral excretion following single doses of furosemide were compared with bumetanide in a random cross-over trial in 17 premature infants. The mean birthweight and gestational age were 889 +/- 85 g and 27 +/- 2 weeks. Following furosemide therapy, significantly higher chloride losses and urine volumes were noted in the first 8-h period compared with the second or third 8-h periods. Following bumetanide therapy, sodium, calcium, and chloride losses and urine volumes were significantly higher in the first 8 h compared with the second or third 8-h periods. Hourly sodium and chloride losses were significantly lower following bumetanide than furosemide during the first two 8-h periods. During the final 8-h period sodium, potassium, chloride, and calcium losses were significantly lower following bumetanide than following furosemide. Sodium loss per urine volume was lower with bumetanide than furosemide but calcium loss tended to be higher. Hence, bumetanide does not appear to be a calcium-sparing diuretic following single-dose therapy.
在一项针对17名早产儿的随机交叉试验中，比较了单次服用速尿和布美他尼后的矿物质排泄情况。平均出生体重和胎龄分别为889±85克和27±2周。速尿治疗后，与第二个或第三个8小时时间段相比，第一个8小时时间段的氯化物损失和尿量显著更高。布美他尼治疗后，与第二个或第三个8小时时间段相比，第一个8小时的钠、钙和氯化物损失以及尿量显著更高。在前两个8小时时间段内，布美他尼治疗后的每小时钠和氯化物损失显著低于速尿。在最后一个8小时时间段内，布美他尼治疗后的钠、钾、氯化物和钙损失显著低于速尿治疗后。布美他尼每尿量的钠损失低于速尿，但钙损失往往更高。因此，单剂量治疗后，布美他尼似乎不是一种保钙利尿剂。
