Beller F K, Intorp H W, Losse H, Loew H, Moenninghoff W, Schmidt E H, Grundmann E
Am J Obstet Gynecol. 1976 Jul 1;125(5):633-9. doi: 10.1016/0002-9378(76)90785-7.
Histologic, immunohistologic, and ultrastructural features are presented of two cases with malignant nephrosclerosis during pregnancy. Primary malignant nephrosclerosis emerges as a clinical entity which can be distinguished from toxemia of pregnancy in the midtrimester and post partum. The first description of malignant nephrosclerosis dates from 40 years ago, but only a few cases were reported associated with pregnancy. Although disseminated intravascular coagulation seems involved, the morphology is different from that of toxemia. Malignant nephrosclerosis reveals a close similarity to the hemolytic uremic syndrome. Early diagnosis by renal biopsy and proper treatment may prevent a lethal outcome due to progressive failure.
本文呈现了两例妊娠期恶性肾硬化症的组织学、免疫组织学及超微结构特征。原发性恶性肾硬化症作为一种临床实体出现，可在妊娠中期及产后与妊娠中毒症相区分。恶性肾硬化症的首次描述可追溯至40年前，但仅有少数与妊娠相关的病例报道。尽管似乎涉及弥散性血管内凝血，但其形态与妊娠中毒症不同。恶性肾硬化症与溶血性尿毒症综合征极为相似。通过肾活检进行早期诊断并给予恰当治疗，可预防因进行性肾衰竭导致的致命后果。
