Shigematsu H, Dikman S H, Churg J, Grishman E
Nephron. 1978;22(4-6):399-408. doi: 10.1159/000181482.
Electron microscopic analysis of subendothelial and mesangial alterations in the glomeruli was performed in 15 cases of malignant nephrosclerosis (MNS). 8 cases showed segmental or diffuse subendothelial accumulation of proteinaceous 'fibrinoid' material associated with thickening of glomerular basement membranes. 2 of these cases also showed similar deposits in the mesangium. When severe, this mesangial insudation resulted in almost complete replacement and destruction of the mesangial matrix. Endothelial injury with alteration of glomerular microcirculation and secondary intravascular coagulation is believed to play a role in the development of the glomerular lesions in MNS.
对15例恶性肾硬化症（MNS）患者的肾小球进行了电子显微镜分析，观察其内皮细胞下和系膜的改变。8例显示节段性或弥漫性内皮细胞下蛋白质样“纤维蛋白样”物质积聚，并伴有肾小球基底膜增厚。其中2例在系膜中也有类似沉积物。严重时，这种系膜内渗几乎导致系膜基质完全被替代和破坏。内皮损伤伴肾小球微循环改变和继发性血管内凝血被认为在MNS肾小球病变的发展中起作用。
