Holland E F, Leather A T, Studd J W
Chelsea and Westminster Hospital, London.
Br J Obstet Gynaecol. 1995 Mar;102(3):238-42. doi: 10.1111/j.1471-0528.1995.tb09101.x.
To evaluate the effect of 75 mg oestradiol implants on the bone mass of older postmenopausal women with osteoporosis.
One year prospective-controlled study.
Thirty-two postmenopausal women over 60 years of age and more than five years postmenopausal with low bone density were recruited. Thirty women completed treatment for one year with 75 mg oestradiol implants. The changes in bone density were compared with a control group of 14 women. The side effects with treatment were documented.
Dual energy X-ray absorptiometry of the lumbar spine and proximal femur using Hologic 1000 QDR before treatment and at one year. Plasma oestradiol assays were performed before and after one year.
The median percentage changes in the treated group after one year was 12.6% at the lumbar spine and 5.22% at the total hip. The increase in vertebral bone density was greatest in women with low initial bone density (r = -0.35, P < 0.05) and those with highest treatment plasma oestradiol levels (r = 0.47, P < 0.01). Side effects were common but most were transient and mild in nature.
75 mg oestradiol implants significantly increase the bone mineral density at the spine and hip of older postmenopausal women with established osteoporosis.
评估75毫克雌二醇植入剂对患有骨质疏松症的绝经后老年女性骨量的影响。
为期一年的前瞻性对照研究。
招募了32名60岁以上、绝经超过五年且骨密度较低的绝经后女性。30名女性接受了75毫克雌二醇植入剂的一年治疗。将骨密度变化与14名女性的对照组进行比较。记录治疗的副作用。
治疗前及治疗一年后，使用Hologic 1000 QDR对腰椎和股骨近端进行双能X线吸收测定。治疗一年前后进行血浆雌二醇检测。
治疗组一年后腰椎的中位百分比变化为12.6%，全髋为5.22%。初始骨密度低的女性（r = -0.35，P < 0.05）和治疗后血浆雌二醇水平最高的女性（r = 0.47，P < 0.01），其椎体骨密度增加最大。副作用很常见，但大多数是短暂且轻微的。
75毫克雌二醇植入剂可显著提高患有已确诊骨质疏松症的绝经后老年女性脊柱和髋部的骨矿物质密度。
