Nishibe A, Morimoto S, Hirota K, Yasuda O, Ikegami H, Yamamoto T, Fukuo K, Onishi T, Ogihara T
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Nihon Ronen Igakkai Zasshi. 1996 May;33(5):353-9. doi: 10.3143/geriatrics.33.353.
To compare the efficacy of estriol (E3) in postmenopausal and senile osteoporosis, we administered orally 1 g/day calcium lactate either alone (control groups) or with 2 mg/day estriol (estrogen groups) for 10 months to 20 postmenopausal women aged 50-65 years and to 29 elderly women aged 70-84 years, and measured their bone mineral density of the lumbar vertebrae by dual energy X-ray absorptiometry. Out of 41 subjects who completed 10 months of treatment, 8 postmenopausal women and 12 elderly women in the estrogen groups had significant (p < 0.05) increases in bone mineral density (5.59 +/- 4.79% of the respective basal values). Ten postmenopausal women and 11 elderly women in the control groups had decreases bone mineral density (-4.02 +/- 7.00% and -3.26 +/- 4.60% of the respective basal values) at the 10th month. Genital bleeding as a side effect of estriol was seen in 6 out 29 elderly subjects at this dose. Moreover, decreases in the levels of calcium, total cholesterol, and triglycerides in serum, and an increase in the level of high-density lipoprotein-cholesterol were seen only in the elderly women receiving estriol. Although a lower dosage of estriol may be recommended for elderly subjects, these observations suggest that hormone replacement therapy with estriol is effective against degenerative osteoporosis, and that low-turnover bones in elderly women are also responsive to estriol.
为比较雌三醇（E3）治疗绝经后和老年性骨质疏松症的疗效，我们对20名年龄在50 - 65岁的绝经后妇女和29名年龄在70 - 84岁的老年妇女，给予每日口服1克乳酸钙，其中一组单独服用（对照组），另一组同时每日服用2毫克雌三醇（雌激素组），持续10个月，并用双能X线吸收法测量她们腰椎的骨密度。在完成10个月治疗的41名受试者中，雌激素组的8名绝经后妇女和12名老年妇女的骨密度有显著增加（分别为各自基础值的5.59±4.79%，p < 0.05）。对照组的10名绝经后妇女和11名老年妇女在第10个月时骨密度下降（分别为各自基础值的-4.02±7.00%和-3.26±4.60%）。在此剂量下，29名老年受试者中有6人出现了作为雌三醇副作用的生殖器出血。此外，仅在接受雌三醇治疗的老年妇女中观察到血清钙、总胆固醇和甘油三酯水平下降，以及高密度脂蛋白胆固醇水平升高。尽管对于老年受试者可能建议使用较低剂量的雌三醇，但这些观察结果表明，雌三醇激素替代疗法对退行性骨质疏松症有效，并且老年妇女的低转换型骨对雌三醇也有反应。
