Vybíral S, Veselá R
Department of Physiology and Development Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Physiol Res. 1994;43(6):359-63.
Haloperidol when applied intraperitoneally to cold-exposed febrile rabbits induces a strong hypothermic effect. This effect is due to the downward shift of the threshold central temperature for induction of cold thermogenesis and vasomotion. The shift occurs during the early phase of the fever and is less prominent during the late phase of the fever. The hypothermic effect of high doses of haloperidol can eliminate the increase of body temperature in febrile individuals.
当向冷暴露的发热兔腹腔注射氟哌啶醇时,会产生强烈的体温过低效应。这种效应是由于诱导冷生热和血管运动的阈值中心温度向下移动所致。这种移动发生在发热的早期阶段,而在发热的后期阶段不太明显。高剂量氟哌啶醇的体温过低效应可以消除发热个体的体温升高。