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神经降压素对家兔的热效应。

Hyperthermic effect of neurotensin in the rabbit.

作者信息

Vybíral S, Nacházel J, Janský L

出版信息

Pflugers Arch. 1986 Mar;406(3):312-4. doi: 10.1007/BF00640920.

DOI:10.1007/BF00640920
PMID:3960708
Abstract

Neurotensin injected into the anterior hypothalamus of the rabbit induces a consistent upward shift of the threshold core temperatures for inducing cold thermogenesis, peripheral vasomotor tone and respiratory evaporative heat loss, while leaving the efficiency and the intensity of these thermoregulatory outputs unchanged. Neurotensin injections into the PH are without effect on body temperature control. The effect of neurotensin is interpreted as a selective inhibition of activity of warm sensors in the anterior hypothalamus. The possible mediating role of dopaminergic pathways in the neurotensin action is discussed.

摘要

向兔的下丘脑前部注射神经降压素会导致诱发冷产热、外周血管舒缩张力和呼吸蒸发散热的阈值核心温度持续向上偏移,而这些体温调节输出的效率和强度保持不变。向正中隆起注射神经降压素对体温控制没有影响。神经降压素的作用被解释为对下丘脑前部温觉感受器活动的选择性抑制。文中讨论了多巴胺能通路在神经降压素作用中可能的介导作用。

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1
Hyperthermic effect of neurotensin in the rabbit.神经降压素对家兔的热效应。
Pflugers Arch. 1986 Mar;406(3):312-4. doi: 10.1007/BF00640920.
2
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本文引用的文献

1
Hypothermia elicited by the intracerebral microinjection of neurotensin.脑室内微量注射神经降压素引起的体温过低。
Peptides. 1980 Winter;1(4):333-9. doi: 10.1016/0196-9781(80)90011-x.
2
Opposing effects of hypothalamic cooling on threshold and sensitivity of metabolic response to body cooling in rabbits.下丘脑冷却对家兔身体冷却代谢反应阈值和敏感性的相反作用。
J Physiol. 1982 Jan;322:139-50. doi: 10.1113/jphysiol.1982.sp014028.
3
Neurotensin and thermoregulation.
Ann N Y Acad Sci. 1982;400:268-82. doi: 10.1111/j.1749-6632.1982.tb31575.x.
4
Neurotensin perfusion of rat hypothalamus: dissociation of dopamine release from body temperature change.大鼠下丘脑的神经降压素灌注:多巴胺释放与体温变化的分离
Neuroscience. 1984 May;12(1):241-53. doi: 10.1016/0306-4522(84)90150-7.
5
Neurotensin-induced hypothermia: evidence for an interaction with dopaminergic systems and the hypothalamic--pituitary--thyroid axis.神经降压素诱导的体温过低:与多巴胺能系统及下丘脑 - 垂体 - 甲状腺轴相互作用的证据
Brain Res. 1980 Aug 11;195(1):69-84. doi: 10.1016/0006-8993(80)90867-7.
6
Evaluation of neurotensin's thermolytic action by ICV infusion with receptor antagonists and a Ca++ chelator.
Pharmacol Biochem Behav. 1983 Sep;19(3):477-81. doi: 10.1016/0091-3057(83)90123-5.
7
Neuropeptides and thermoregulation: the interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins.
Peptides. 1982 Jan-Feb;3(1):1-6. doi: 10.1016/0196-9781(82)90132-2.
8
Effects of intraventricular administration of neurotensin and somatostatin on thermoregulation in the rat.脑室内注射神经降压素和生长抑素对大鼠体温调节的影响。
Neuropharmacology. 1981 Jul;20(7):715-8. doi: 10.1016/0028-3908(81)90122-2.
9
The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami.从牛下丘脑分离出一种新的降压肽——神经降压素。
J Biol Chem. 1973 Oct 10;248(19):6854-61.
10
Neurotensin-induced hypothermia in the rat: structure-activity studies.神经降压素诱导大鼠体温过低:构效关系研究
Neuropharmacology. 1978 Feb;17(2):109-13. doi: 10.1016/0028-3908(78)90122-3.