Purnell D M
Am J Pathol. 1976 Jun;83(3):547-56.
The effect of killed Corynebacterium parvum vaccine on the course of murine aspergillosis is described. A grid-counting technique was employed to quantitate tissue invasion by Aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed C. parvum vaccine. Simultaneous treatment of mice with C. parvum and A. nidulans significantly increased the mortality rate, in contrast to treatment of mice with C. parvum prior to or following A. nidulans, which had no significant effect on mortality. Fungal invasion of the tissues of the brain and kidneys was significantly increased in mice pretreated or posttreated with C. parvum, but fungal invasion of the heart was not effected by these treatements. Simultaneous treatment of mice with C. parvum and A. nidulans significantly increased fungal invasion of the heart but did not effect tissue invasion of the brain and kidneys. It was concluded that killed C. parvum vaccine reduces host resistance to Aspergillus infection and facilitates the curse of fatal murine aspergillosis. These results suggest further caution in applying systemic C. parvum in the therapy of human neoplasia.
本文描述了灭活短小棒状杆菌疫苗对小鼠曲霉病病程的影响。采用网格计数技术对正常小鼠以及经全身注射灭活短小棒状杆菌疫苗处理的小鼠的脑、心脏和肾脏（靶器官）中构巢曲霉的组织侵袭情况进行定量分析。与在构巢曲霉感染之前或之后注射短小棒状杆菌疫苗相比，同时注射短小棒状杆菌疫苗和构巢曲霉显著提高了小鼠死亡率，而先注射或后注射短小棒状杆菌疫苗对死亡率无显著影响。预先或事后接受短小棒状杆菌疫苗处理的小鼠，其脑和肾脏组织中的真菌侵袭显著增加，但心脏组织中的真菌侵袭不受这些处理的影响。同时注射短小棒状杆菌疫苗和构巢曲霉显著增加了心脏组织中的真菌侵袭，但对脑和肾脏的组织侵袭无影响。研究得出结论，灭活短小棒状杆菌疫苗会降低宿主对曲霉感染的抵抗力，并加速致命性小鼠曲霉病的病程。这些结果提示，在将全身注射短小棒状杆菌疫苗应用于人类肿瘤治疗时应更加谨慎。
