Gunnlaugsson G, da Silva M C, Smedman L
Centre of Maternal and Child Health, Guinea-Bissau.
Acta Paediatr. 1995 Apr;84(4):398-401. doi: 10.1111/j.1651-2227.1995.tb13658.x.
Colostrum protects the newborn from intestinal infection by its content of secretory immunoglobulin A and other immediately acting factors. It may also induce maturation of the child's gastrointestinal immune defences, thus contributing to the protection against diarrhoeal disease later in infancy. To test this hypothesis, a case-control study on breast feeding and diarrhoea was carried out in a periurban community in Guinea-Bissau. The child's age at the start of breast feeding was ascertained soon after birth (n = 279). Subsequent cases of acute diarrhoea (n = 66) were identified at 3-monthly examinations, and four concurrent controls were randomly selected among attendants. Three separate estimates of association showed that the cases tended to have started breast feeding later after birth than the diarrhoea-free controls, but no single test was statistically significant. Early breast feeding might have consequences for diarrhoeal morbidity after the neonatal period.
初乳因其所含的分泌型免疫球蛋白A和其他即时起作用的因子，可保护新生儿免受肠道感染。它还可能促使儿童胃肠道免疫防御系统成熟，从而有助于预防婴儿后期的腹泻疾病。为验证这一假设，在几内亚比绍的一个城郊社区开展了一项关于母乳喂养与腹泻的病例对照研究。出生后不久即确定了开始母乳喂养时儿童的年龄（n = 279）。在每3个月一次的检查中识别出随后发生的急性腹泻病例（n = 66），并在陪同人员中随机挑选4名同期对照。三项独立的关联估计显示，病例开始母乳喂养的时间往往比未患腹泻的对照出生后更晚，但没有一项检验具有统计学显著性。早期母乳喂养可能对新生儿期后的腹泻发病率有影响。
