Christophe J
Laboratoire de Chirurgie expérimentale, faculté de Médecine de l'Université libre de Bruxelles.
Bull Mem Acad R Med Belg. 1994;149(5-7):271-7; discussion 277-8.
The mRNA for a glucagon receptor is present in five glucagon-responsive tissues of rat, including the liver, heart, pancreatic islets, kidneys and adipose tissue. The mature mRNA of this receptor is likely to derive from one gene only in all tissues investigated. The maturation of the pre-mRNA requires the splicing of 11 introns. This proceeds stepwise at the 5' end but a single intronless ORF is finally operative. The receptor is a glycoprotein endowed with 485 amino acids (including the signal peptide).
胰高血糖素受体的信使核糖核酸存在于大鼠的五种对胰高血糖素产生反应的组织中，包括肝脏、心脏、胰岛、肾脏和脂肪组织。在所有研究的组织中，该受体的成熟信使核糖核酸可能仅来源于一个基因。前体信使核糖核酸的成熟需要11个内含子的剪接。这在5'端逐步进行，但最终起作用的是一个无内含子的单一开放阅读框。该受体是一种糖蛋白，含有485个氨基酸（包括信号肽）。
