Hansen L H, Abrahamsen N, Nishimura E
Department of Molecular Signalling, Hagedorn Research Institute, Gentofte, Denmark.
Peptides. 1995;16(6):1163-6. doi: 10.1016/0196-9781(95)00078-x.
In addition to glucagon's role in regulating glucose production from the liver, a number of extrahepatic effects of glucagon have been reported. We have therefore examined various rat tissues for glucagon receptor mRNA expression. In liver, kidney, heart, adipose tissue, spleen, pancreatic islets, ovary, and thymus, glucagon receptor mRNA expression was found to be relatively abundant whereas lower levels were detected in stomach, small intestine, adrenal gland, thyroid, and skeletal muscle. The presence of glucagon receptor mRNA in tissues known to be responsive to glucagon suggests that these effects are mediated by specific glucagon receptors. Furthermore, the finding of glucagon receptor mRNA in the spleen, thymus, thyroid, adrenal gland, ovary, and skeletal muscle, where glucagon is not generally considered to act, indicates that there may be novel actions of glucagon that have yet to be determined.
除了胰高血糖素在调节肝脏葡萄糖生成中的作用外，已有报道称胰高血糖素还具有许多肝外效应。因此，我们检测了多种大鼠组织中胰高血糖素受体mRNA的表达。在肝脏、肾脏、心脏、脂肪组织、脾脏、胰岛、卵巢和胸腺中，发现胰高血糖素受体mRNA表达相对丰富，而在胃、小肠、肾上腺、甲状腺和骨骼肌中检测到的水平较低。已知对胰高血糖素产生反应的组织中存在胰高血糖素受体mRNA，这表明这些效应是由特定的胰高血糖素受体介导的。此外，在通常认为胰高血糖素不起作用的脾脏、胸腺、甲状腺、肾上腺、卵巢和骨骼肌中发现了胰高血糖素受体mRNA，这表明胰高血糖素可能存在尚未确定的新作用。
