Corless D J, Holland J, Wastell C
Department of Academic Surgery, Chelsea and Westminster Hospital, London, UK.
Br J Surg. 1995 Mar;82(3):368-70. doi: 10.1002/bjs.1800820328.
The effect of the starch-containing powder BioSorb on wound healing was examined in an immunocompetent and a T cell-deficient animal model. Wounds were tested by tensionometry to give values of resilience, ultimate strength, toughness and extension. Starch significantly decreased the resilience (P < 0.03), ultimate strength (P < 0.004), and toughness (P < 0.006) of wounds in the immunocompetent model but was not shown to affect the healing of wounds in T cell-depleted animals. When the uncontaminated wounds of the two groups were compared, those from T cell-depleted animals were tougher (P < 0.04) and less extensile (P < 0.0002). These results suggest that starch impairs wound healing by its effect on the T cell-mediated immune system, and that this system may also be involved in regulation of the reparative process because its absence leads to tougher wounds.
在具有免疫能力和T细胞缺陷的动物模型中，研究了含淀粉粉末BioSorb对伤口愈合的影响。通过张力测定法检测伤口，得出弹性、极限强度、韧性和伸展度的值。在具有免疫能力的模型中，淀粉显著降低了伤口的弹性（P < 0.03）、极限强度（P < 0.004）和韧性（P < 0.006），但未显示对T细胞耗竭动物的伤口愈合有影响。当比较两组未受污染的伤口时，T细胞耗竭动物的伤口更坚韧（P < 0.04）且伸展性更小（P < 0.0002）。这些结果表明，淀粉通过其对T细胞介导的免疫系统的作用损害伤口愈合，并且该系统可能也参与修复过程的调节，因为其缺失会导致伤口更坚韧。
