球形红杆菌反硝化亚种的二甲基亚砜还原酶催化的烷基芳基亚砜对映选择性脱氧反应
Enantioselective deoxygenation of alkyl aryl sulfoxides by DMSO reductase from Rhodobacter sphaeroides f.s. denitrificans.
作者信息
Abo M, Tachibana M, Okubo A, Yamazaki S
机构信息
Department of Applied Biological Chemistry, University of Tokyo, Japan.
出版信息
Bioorg Med Chem. 1995 Feb;3(2):109-12. doi: 10.1016/0968-0896(95)00004-z.
PMID:7796044
Abstract
The substrate specificity and enantioselectivity of DMSO reductase from Rhodobacter sphaeroides f.s. denitrificans were studied on a series of alkyl aryl sulfoxides as substrate. The enzyme was found to catalyze deoxygenation of (S)-sulfoxides predominantly. (R)-Sulfoxides were recovered with a high enantiomeric excess.
摘要
以一系列烷基芳基亚砜为底物，研究了脱氮红假单胞菌中DMSO还原酶的底物特异性和对映体选择性。发现该酶主要催化（S）-亚砜的脱氧反应。回收得到的（R）-亚砜具有很高的对映体过量值。
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