The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
作者信息
Groutas W C, Chong L S, Venkataraman R, Epp J B, Kuang R, Houser-Archield N, Hoidal J R
机构信息
Department of Chemistry, Wichita State University, KS 67260-0051, USA.
出版信息
Bioorg Med Chem. 1995 Feb;3(2):187-93. doi: 10.1016/0968-0896(95)00013-7.
PMID:7796053
Abstract
The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.
摘要
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