在大鼠腰脊髓中显示P物质受体样免疫反应性的脊髓臂旁束神经元。

Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat.

作者信息

Ding Y Q, Takada M, Shigemoto R, Mizumo N

机构信息

Department of Morpholgoical Brain Science, Faculty of Medicine, Kyoto University, Japan.

出版信息

Brain Res. 1995 Mar 20;674(2):336-40. doi: 10.1016/0006-8993(95)00022-i.

DOI:10.1016/0006-8993(95)00022-i

PMID:7796113

Abstract

By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, SPR-like immunoreactive (SPR-LI) neurons sending their axons to the lateral parabrachial region were observed in the lumbar spinal cord of the rat. After injection of Fluoro-Gold into the lateral parabrachial region, retrogradely labeled neurons with SPR-LI were seen frequently in lamina I and the lateral spinal nucleus, and occasionally in laminae IV and V, with a predominantly contralateral distribution. Some of these neurons, especially those in lamina I, may convey nociceptive information to the lateral parabrachial region.

摘要

通过使用P物质受体（SPR）免疫荧光组织化学结合荧光逆行标记法，在大鼠腰脊髓中观察到将轴突投射至外侧臂旁核区域的SPR样免疫反应性（SPR-LI）神经元。将荧光金注射到外侧臂旁核区域后，在I层和脊髓外侧核中经常可见具有SPR-LI的逆行标记神经元，偶尔在IV层和V层中也可见到，且主要呈对侧分布。其中一些神经元，尤其是I层中的神经元，可能将伤害性信息传递至外侧臂旁核区域。