Immunocytochemical evidence for vesicular storage of glutamate in cat spinocervical and cervicothalamic tract terminals.

The densities of synaptic vesicles and gold particles, signaling fixed glutamate, were examined in spinocervical and cervicothalamic tract terminals. Statistically significant positive correlations between these parameters were detected in both terminal populations, whereas presumed inhibitory profiles displayed insignificant or negative correlations. These findings indicate a vesicular storage of glutamate in spinocervical and cervicothalamic tract terminals, and thus provide further evidence for glutamate as a neurotransmitter in the spinocervicothalamic pathway.