Gieroba Z J, Zhu B S, Blessing W W, Wesselingh S L
Department of Medicine, Flinders University, Bedford Park, Australia.
Brain Res. 1995 Mar 27;675(1-2):329-32. doi: 10.1016/0006-8993(95)00016-j.
After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.
将1型单纯疱疹病毒注入大鼠颈迷走神经后，延髓中存在经跨神经元标记的含病毒神经元和神经胶质细胞。大脑的相同区域存在含Fos的细胞核。双重标记程序显示，大多数病毒阳性神经元也含有Fos阳性细胞核。中枢神经系统内HSV1抗原的出现与神经元和神经胶质细胞中的Fos表达相关。
