Ozaki N, Sugiura Y, Yamamoto M, Nishiyama Y
Department of Anatomy, Fukushima Medical College, Japan.
Neurosci Lett. 1996 Sep 20;216(1):61-4. doi: 10.1016/0304-3940(96)13009-3.
After the inoculation of a highly attenuated strain of herpes simplex virus (HSV) type 1 into the mouse hind-paw planter skin, a few neurons and glial cells were viral antigen-positive in the dorsal root ganglia (DRGs) and anterior horn of L4 and L5 segments of the lumbar spinal cord. Fos-containing nuclei, however, were not found in the DRGs or the lumbar cord segments. After the inoculation of a highly neuroinvasive strain of HSV type 2, many virus-positive neurons and glial cells were detected in the DRGs, anterior and posterior horns at L4 and L5; Fos-containing nuclei were also observed in spinal neurons except for motoneurons. The results indicate that transneuronal infection of HSV induces Fos expression in spinal neurons.
将1型单纯疱疹病毒（HSV）的高减毒株接种到小鼠后足跖皮肤后，在背根神经节（DRG）以及腰髓L4和L5节段的前角中，少数神经元和神经胶质细胞呈病毒抗原阳性。然而，在DRG或腰髓节段中未发现含Fos的细胞核。接种2型高神经侵袭性HSV毒株后，在DRG、L4和L5的前角和后角中检测到许多病毒阳性神经元和神经胶质细胞；除运动神经元外，在脊髓神经元中也观察到含Fos的细胞核。结果表明，HSV的跨神经元感染可诱导脊髓神经元中Fos表达。
