Maibach H I
Annu Rev Pharmacol Toxicol. 1976;16:401-11. doi: 10.1146/annurev.pa.16.040176.002153.
The fields of cutaneous pharmacology and toxicology existed as long as man used topical therapy; some medicaments were helpful and others harmful. This review documents recent progress in these fields in terms of the experimental method. Emphasis has been given to conceptual and methodologic progress rather than a list of new molecules. As signs of the advent of the maturity of these fields, a graduate school course has recently been completed, one text has been published (7), and at least two are in preparation. It is likely that the next review of this topic in this series will reflect this considerable progress in terms of relevance to man.
自从人类开始使用局部治疗方法以来，皮肤药理学和毒理学领域就已存在；有些药物有益，而有些则有害。本综述从实验方法的角度记录了这些领域的最新进展。重点在于概念和方法学上的进展，而非新分子的罗列。作为这些领域走向成熟的标志，最近完成了一门研究生课程，已出版了一本教材（7），至少还有两本正在编写中。本系列下一次对该主题的综述很可能会在与人类相关性方面反映出这一重大进展。
