Duprat P, Gradiski D, Marignac B
Eur J Toxicol Environ Hyg. 1976 Jan-Feb;9(1):43-53.
This is a study on the irritant capacity of two isocyanates (T. D. I. Toluene diisocyanate and M. D. I. diphenyl methane diisocyanate). The experiment was carried out on the hide and ocular mucous membrane of albino rabbits, using Draize method as well as the method for appraising cosmetics. An histopathological examination of the evolution of the lesions was then achieved together with a study on the delayed allergenic capacity. This study was carried out on albino guinea-pig hides using Kligman and Magnusson technique. In these experimental conditions, the conclusions were the following:--on rabbit hide, T. D. I. is a medium irritant, more caustic than M. D. I.,--on ocular mucous membrane, M. D. I. is a mild irritant; T. D. I. a strong one,--on guinea-pig hide, T. D. I. and M. D. I. may induce cutaneous sensitivity similar to contact allergy. Their allergenic capacity is long lasting but varies according to the allergen concentration.
这是一项关于两种异氰酸酯（甲苯二异氰酸酯和二苯基甲烷二异氰酸酯）刺激能力的研究。实验在白化兔的皮肤和眼黏膜上进行，采用了德莱兹方法以及化妆品评价方法。随后对病变的演变进行了组织病理学检查，并对迟发性过敏能力进行了研究。该研究在白化豚鼠的皮肤上采用克利格曼和马格努松技术进行。在这些实验条件下，得出了以下结论：——在兔皮肤上，甲苯二异氰酸酯是一种中度刺激物，比二苯基甲烷二异氰酸酯腐蚀性更强；——在眼黏膜上，二苯基甲烷二异氰酸酯是一种轻度刺激物；甲苯二异氰酸酯是一种强刺激物；——在豚鼠皮肤上，甲苯二异氰酸酯和二苯基甲烷二异氰酸酯可能诱发类似于接触性过敏的皮肤敏感性。它们的致敏能力持久，但会因过敏原浓度而异。
