Qui Y, Tian K, Yang D, Zhang Q, Wang Z, Huang Z, Sun M, Mingzhang S
Department of Reproductive Physiology, Shandong Institute of Family Planning, China.
Contraception. 1995 Apr;51(4):261-3. doi: 10.1016/0010-7824(95)00043-a.
The change in carnitine content in seminal plasma after reversible injection occlusion of vas deferens (RIOVD) was observed. RIOVD is a safe, effective and simple method of male fertility control. Carnitine was determined by microenzymatic method. The incidence of sperm disappearance increased with the duration of RIOVD and reached 90% at the end of 12 months after operation. Before RIOVD, the mean value of carnitine in seminal plasma was 336.9 +/- 78.1 nmol/ml (X +/- SD, n = 58); after RIOVD, the mean value of seminal plasma carnitine was 112.7 +/- 50.7 nmol/ml (n = 172) in the group with sperm disappearance, and 172.5 +/- 71.7 nmol/ml (n = 51) in the group without sperm disappearance. There was a significant difference in carnitine content between pre-operation and postoperation (p < 0.01). After RIOVD, the carnitine concentration in seminal plasma of the group with sperm disappearance was lower than that of the group without sperm disappearance (p < 0.01). The results suggest that carnitine content in seminal plasma following RIOVD may be a reference index for judging the success or failure of the operation.
观察了输精管可逆性注射堵塞（RIOVD）后精浆中肉碱含量的变化。RIOVD是一种安全、有效且简便的男性生育控制方法。采用微量酶法测定肉碱。精子消失的发生率随RIOVD持续时间增加，术后12个月末达到90%。RIOVD前，精浆中肉碱平均值为336.9±78.1 nmol/ml（X±SD，n = 58）；RIOVD后，精子消失组精浆肉碱平均值为112.7±50.7 nmol/ml（n = 172），无精子消失组为172.5±71.7 nmol/ml（n = 51）。术前与术后肉碱含量有显著差异（p < 0.01）。RIOVD后，精子消失组精浆中肉碱浓度低于无精子消失组（p < 0.01）。结果提示，RIOVD后精浆中肉碱含量可能是判断手术成败的一个参考指标。
