Meisser A, Campana A, Bischof P
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland.
Hum Reprod. 1996 Mar;11(3):574-8. doi: 10.1093/humrep/11.3.574.
Ovarian cancer marker CA 125 was measured in human seminal plasma, and the concentrations ranged between 22 and 1149 U/ml, and between 39 and 4711 U/ejaculate. This very high patient-to-patient variability was in contrast to a much lower within-patient variability, which was comparable to that of other semen parameters. No significant differences in CA 125 concentration were found in seminal plasma from normospermic patients, patients with male factors, vasectomized men, and in aliquots of samples which led to a pregnancy, via artificial insemination or in-vitro fertilization. The seminal plasma CA 125 concentration was not correlated with sperm count, motility and morphology. In contrast, seminal plasma CA 125 concentrations correlated with the age of the patient (P < 0.001) and inversely with the volume of the ejaculate (P < 0.001). These correlations were independent of each other. CA 125 did not correlate with the prostatic marker zinc, but did do so with the seminal vesicle marker fructose and the epididymal marker carnitine.
在人类精浆中检测了卵巢癌标志物CA 125，其浓度范围在22至1149 U/ml之间，每次射精的浓度范围在39至4711 U之间。患者之间这种非常高的变异性与患者自身较低的变异性形成对比，后者与其他精液参数的变异性相当。在正常精子患者、有男性因素的患者、输精管结扎的男性以及通过人工授精或体外受精导致妊娠的样本等分试样的精浆中，未发现CA 125浓度有显著差异。精浆中CA 125浓度与精子计数、活力和形态无关。相反，精浆中CA 125浓度与患者年龄相关（P < 0.001），与射精量呈负相关（P < 0.001）。这些相关性相互独立。CA 125与前列腺标志物锌无关，但与精囊标志物果糖和附睾标志物肉碱有关。
