Weng Y, Wang Y, Zhang X
Department of Genetics and Healthy Birth, Chongqing University of Medical Science.
Zhonghua Fu Chan Ke Za Zhi. 1995 Mar;30(3):142-4.
Chromosomal centromeric dots (Cd) of peripheral blood in 20 couples with spontaneous abortion and 10 normal couples were studied by Cd-banding technique. The frequencies of Cd loss and centromeric dots-nucleolar organizer region (Cd-NOR) fusion were 0.36 +/- 0.15/cell and 0.31 +/- 0.20/cell in the couples with abortion, 0.22 +/- 0.13/cell and 0.20 +/- 0.19/cell in normal couples respectively. These results showed that frequencies of Cd loss and Cd-NOR fusion in couples of spontaneous abortion were significantly higher than those in the normal couples. We suggested that the occurrence of spontaneous abortion in human might casually relate to the changes of Cd.
采用着丝粒带（Cd）技术研究了20对自然流产夫妇及10对正常夫妇外周血染色体着丝粒点（Cd）。自然流产夫妇中Cd丢失频率及着丝粒点 - 核仁组织者区（Cd - NOR）融合频率分别为0.36±0.15/细胞和0.31±0.20/细胞，正常夫妇中分别为0.22±0.13/细胞和0.20±0.19/细胞。结果表明，自然流产夫妇中Cd丢失及Cd - NOR融合频率显著高于正常夫妇。我们认为人类自然流产的发生可能与Cd的变化存在偶然关联。
