Zhang W, Liu Z, Yang D
Department of Internal Medicine, First Affiliated Hospital, Xi'an Medical University.
Zhonghua Nei Ke Za Zhi. 1995 Feb;34(2):95-7.
The presence and dynamic change of autoantibody against ADP/ATP carrier in patients with dilated cardiomyopathy (DCM) was studied by using indirect micro-solid-phase radioimmunoassay. A significant antibody titre was present in 16 of 48 DCM patients and most of them were in early stage of the disease. The titre of anti-ADP/ATP carrier antibody in DCM patients decreased gradually in a follow-up period of three months. The titre of this antibody in the serum from patients with coronary and rheumatic heart disease were within normal limits. Anti-ADP/ATP carrier antibody may play an important role in the pathogenesis, diagnosis and treatment of DCM.
采用间接微量固相放射免疫分析法，研究扩张型心肌病（DCM）患者抗ADP/ATP载体自身抗体的存在情况及其动态变化。48例DCM患者中，16例存在显著的抗体滴度，且大多数处于疾病早期。在3个月的随访期内，DCM患者抗ADP/ATP载体抗体滴度逐渐下降。冠心病和风湿性心脏病患者血清中该抗体滴度在正常范围内。抗ADP/ATP载体抗体可能在DCM的发病机制、诊断及治疗中起重要作用。
